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A new approach to procyanidins synthesis with potent anti-adipogenic effects

Authors
Jeong, Gyeong HanCho, Jae-HyeonKim, Tae Hoon
Issue Date
15-Aug-2019
Publisher
Pergamon Press Ltd.
Keywords
(+)-Catechin; Oligomerization; Dielectric barrier discharge plasma; Pancreatic lipase; Adipocyte differentiation
Citation
Bioorganic & Medicinal Chemistry Letters, v.29, no.16, pp 2079 - 2084
Pages
6
Indexed
SCI
SCIE
SCOPUS
Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume
29
Number
16
Start Page
2079
End Page
2084
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/8850
DOI
10.1016/j.bmcl.2019.07.008
ISSN
0960-894X
1464-3405
Abstract
Convenient structure modification of (+)-catechin (1) induced by nonthermal dielectric barrier discharge (DBD) plasma treatment afforded three novel methylene-linked flavan-3-ol oligomers, methylenetetracatechin (2), methylenetricatechin (3), and methylenedicatechin (4), together with two known catechin dimers, bis 8,8'-catechinylmethane (5) and bis 6,8'-catechinylmethane (6). The structures of the three new catechin oligomers 2-4 with methylene bridges were elucidated by detailed 1D- and 2D-NMR analysis, and the absolute configurations were established by the observation of circular dichroism (CD). The novel products 2 and 3 showed significantly enhanced anti-adipogenic capacities against both pancreatic lipase and differentiation of 3T3-L1 preadipocytes compared to the parent (+)-catechin.
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Cho, Jae Hyeon
수의과대학 (수의학과)
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