Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndromeopen access
- Kim, Minji; Ahn, Youngmin; Yoo, Young; Kim, Dong-Kyu; Yang, Hyeon-Jong; Park, Hae-Sim; Lee, Hyun Jong; Kim, Mi-Ae; Jeong, Yi Yeong; Kim, Bong-Seong; Bae, Woo Yong; Jang, An-Soo; Park, Yang; Koh, Young-Il; Lee, Jaechun; Lim, Dae Hyun; Kim, Jeong Hee; Lee, Sang Min; Kim, Yong Min; Jun, Young Joon; Kim, Hyo Yeol; Kim, Yunsun; Choi, Jeong-Hee
- Issue Date
- YONSEI UNIV COLL MEDICINE
- Pollen-food allergy syndrome; pollen; food allergy; anaphylaxis
- YONSEI MEDICAL JOURNAL, v.60, no.10, pp.960 - 968
- Journal Title
- YONSEI MEDICAL JOURNAL
- Start Page
- End Page
- Purpose: Many studies have reported that pollen-food allergy syndrome (PFAS) can cause anaphylaxis. No comprehensive investigations into anaphylaxis in PFAS have been conducted, however. In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis. Materials and Methods: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130). Results: The most common cause of anaphylaxis in PFAS was peanut (33.3%), apple (22.2%), walnut (22.2%), pine nut (18.5%), peach (14.8%), and ginseng (14.8%). Anaphylaxis was significantly associated with the strength of sensitization to alder, hazel, willow, poplar, timothy, and ragweed (p<0.05, respectively). Multivariable analysis revealed that the presence of atopic dermatitis [odds ratio (OR), 3.58; 95% confidence interval (CI), 1.25-10.23; p=0.017]; sensitization to hazel (OR, 5.27; 95% CI, 1.79-15.53; p=0.003), timothy (OR, 11.8; 95% CI, 2.70-51.64; p=0.001), or ragweed (OR, 3.18; 95% CI, 1.03-9.87; p=0.045); and the number of culprit foods (OR, 1.25; 95% CI, 1.15-1.37; p<0.001) were related to the development of anaphylaxis in PFAS. Conclusion: The most common culprit foods causing anaphylaxis in PFAS were peanut and apple. The presence of atopic dermatitis; sensitization to hazel, timothy, or ragweed; and a greater number of culprit foods were risk factors for anaphylaxis in PFAS.
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- College of Medicine > Department of Medicine > Journal Articles
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