The atypical chemokine receptor 4 in red sea bream (Pagrus major): Molecular characterization and gene expression analysis
- Choi, Kwang-Min; Hwang, Seong Don; Joo, Min Soo; Hwang, Jee Youn; Kwon, Mun-Gyeong; Jeong, Ji-Min; Seo, Jung Soo; Jee, Bo-Yeong; Park, Chan-Il
- Issue Date
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Pagrus major; Atypical chemokine receptor 4; Streptococcus iniae; Red sea bream iridovirus
- FISH & SHELLFISH IMMUNOLOGY, v.93, pp.50 - 54
- Journal Title
- FISH & SHELLFISH IMMUNOLOGY
- Start Page
- End Page
- Atypical chemokine receptor 4 (ACKR4) is regulated by cytokines, binds chemokines and regulates the chemokine gradient. We verified the cDNA sequence by confirming ACKR4 from red sea bream (PmACKR4) by next generation sequencing (NGS) and analysed the molecular characteristics and gene expression profile. In the analysis using the predicted amino acid sequence of PmACKR4, a highly conserved G protein-coupled receptor 1 region and two cysteine residues were identified and included in the ACKR4 teleost cluster in the phylogenetic analysis. In healthy red sea bream, PmACKR4 mRNA was expressed at the highest levels in head kidney and was upregulated in all immune -related tissues used in the experiment after challenges with Streptococcus iniae (S. iniae) and red sea bream iridovirus (RSIV). These results suggest that ACKR4 is highly conserved in red sea bream and may play an important role in the immune system as previously reported. It is thought that ACKR4 acts as a regulator of immune -related cells via immune reactions after pathogenic infection.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 해양과학대학 > 양식생명과학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.