Bilateral ovarian granulocytic sarcoma as the primary manifestation of acute myelogenous leukemia treated with allogenic stem cell transplantation A case reportopen access
- Choi, Jung Yoon; Kim, Hyun-Young; Kang, Min Gyu; Shin, Jeong Kyu; Lee, Won Seop; Song, Haa-Na
- Issue Date
- LIPPINCOTT WILLIAMS & WILKINS
- acute myeloid leukaemia; granulocytic sarcoma; stem cell transplantation
- MEDICINE, v.98, no.52
- Journal Title
- Rationale: Granulocytic sarcoma (GS), also known as chloroma, is a tumor comprising myeloblasts or monoblasts, potentially occurring as an extramedullary mass. Systemic chemotherapy should be used to induce complete remission. However, such patients with chloroma have a poorer treatment outcome than those without extramedullary myeloid sarcomas. Patient concerns: A 30-year-old woman who initially presented with bilateral ovarian masses and splenomegaly was admitted to hospital. Also, her complete blood cell counts showed pancytopenia and blood smear revealed a few immature cells (3%). Diagnoses: A bone marrow biopsy demonstrated acute myelomonocytic leukemia, and the chromosomal analysis revealed a 46, XX, del18 (p11)  karyotype and cytogenetics and molecular markers showed all negative results. Interventions: Since this diagnosis, she received remission-inducing chemotherapy comprising anthracycline and cytarabine, which is a standard regimen for acute myeloid leukemia (AML), and followed by allogenic hematopoietic stem cell transplantation from Human leukocyte antigen (HLA)-identical sibling donor. Outcomes: After transplantation, the bone marrow engrafted successfully without complications. She visited our clinic regularly with no evidence of leukemia relapse or graft-versus host disease. Lessons: This report represents the first case of ovarian GS, wherein treatment was successful with high-dose chemotherapy, followed by allogenic hematopoietic stem cell transplantation without oophorectomy.
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- College of Medicine > Department of Medicine > Journal Articles
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