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Trolox-induced cardiac differentiation is mediated by the inhibition of Wnt/beta-catenin signaling in human embryonic stem cells
- Authors
- Choe, Mu Seog; Yeo, Han Cheol; Bae, Chang Min; Hang, Ho Jae; Baek, Kyung Min; Kim, Joong Sun; Lim, Kyung Seob; Shin, In-Sik; Chang, Woochul; Yun, Seung Pil; Lee, Ho Jin; Lee, Min Young
- Issue Date
- Dec-2019
- Publisher
- Academic Press
- Keywords
- cardiac differentiation; human embryonic stem cells; trolox
- Citation
- Cell Biology International, v.43, no.12, pp 1505 - 1515
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cell Biology International
- Volume
- 43
- Number
- 12
- Start Page
- 1505
- End Page
- 1515
- ISSN
- 1065-6995
1095-8355
- Abstract
- Cardiac differentiation of human pluripotent stem cells may be induced under chemically defined conditions, wherein the regulation of Wnt/beta-catenin pathway is often desirable. Here, we examined the effect of trolox, a vitamin E analog, on the cardiac differentiation of human embryonic stem cells (hESCs). 6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) significantly enhanced cardiac differentiation in a time- and dose-dependent manner after the mesodermal differentiation of hESCs. Trolox promoted hESC cardiac differentiation through its inhibitory activity against the Wnt/beta-catenin pathway. This study demonstrates an efficient cardiac differentiation method and reveals a novel Wnt/beta-catenin regulator.
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