Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing's diseaseopen access
- Authors
- Baek, Yeong-Bin; Ang, Mary Jasmin; Park, Jun-Gyu; Yu, DoHyeon; Park, Seungjo; Lee, Jae-Hyuk; Choi, Jihye; Cho, Kyoung-Oh
- Issue Date
- Dec-2019
- Publisher
- JAPAN SOC VET SCI
- Keywords
- adrenocorticotropic hormone; canine; Cushing' s disease; neuroendocrine tumor
- Citation
- JOURNAL OF VETERINARY MEDICAL SCIENCE, v.81, no.12, pp.1863 - 1867
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF VETERINARY MEDICAL SCIENCE
- Volume
- 81
- Number
- 12
- Start Page
- 1863
- End Page
- 1867
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/8441
- DOI
- 10.1292/jvms.19-0386
- ISSN
- 0916-7250
- Abstract
- An 18-year- old male Yorkshire Terrier was admitted with a history of neurological signs including dullness and progressive tetraparesis. Physical examination revealed bilaterally symmetrical alopecia and pot-bellied abdomen. Computed tomography and necropsy examination showed a mass across the frontal sinus and cerebral frontal lobe, bilateral adrenocortical hyperplasia, and hepatomegaly. Histopathologically, the tumor lesions consisted of sheets, nests, or cords of small- to medium-sized round-to-polyhedral cells. Adrenal cortex showed bilateral diffuse cellular proliferation, and some hepatocytes showed intracytoplasmic glycogen accumulation. Immunohistochemically, the tumor cells were positive for pancytokeratin, chromogranin-A, neuron-specific enolase, S100, synaptophysin, and thyroid transcription factor-1 but negative for microtubule-associated proein-2 and neurofilament, leading to the diagnosis of neuroendocrine tumor. These tumor cells were also positive for adrenocorticotropic hormone.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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