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Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory functionopen access

Authors
Lin, Sheng-JiaVona, BarbaraPorter, Hillary M.Izadi, MahmoudHuang, KevinLacassie, YvesRosenfeld, Jill A.Khan, SaadullahPetree, CassidyAli, Tayyiba A.Muhammad, NazifKhan, Sher A.Muhammad, NoorLiu, PengfeiHaymon, Marie-LouiseRueschendorf, FranzKong, Il-KeunSchnapp, LindaShur, NatashaChorich, LynnLayman, LawrenceHaaf, ThomasPourkarimi, EhsanKim, Hyung-GooVarshney, Gaurav K.
Issue Date
Oct-2022
Publisher
WILEY
Keywords
autosomal recessive; biallelic variants; C; elegans; translation initiation sites; tryptophanyl-tRNA synthetase 1 (WARS1); WHEP domain; zebrafish
Citation
HUMAN MUTATION, v.43, no.10, pp.1472 - 1489
Indexed
SCIE
SCOPUS
Journal Title
HUMAN MUTATION
Volume
43
Number
10
Start Page
1472
End Page
1489
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/829
DOI
10.1002/humu.24435
ISSN
1059-7794
Abstract
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for faithful assignment of amino acids to their cognate tRNA. Variants in ARS genes are frequently associated with clinically heterogeneous phenotypes in humans and follow both autosomal dominant or recessive inheritance patterns in many instances. Variants in tryptophanyl-tRNA synthetase 1 (WARS1) cause autosomal dominantly inherited distal hereditary motor neuropathy and Charcot-Marie-Tooth disease. Presently, only one family with biallelic WARS1 variants has been described. We present three affected individuals from two families with biallelic variants (p.Met1? and p.(Asp419Asn)) in WARS1, showing varying severities of developmental delay and intellectual disability. Hearing impairment and microcephaly, as well as abnormalities of the brain, skeletal system, movement/gait, and behavior were variable features. Phenotyping of knocked down wars-1 in a Caenorhabditis elegans model showed depletion is associated with defects in germ cell development. A wars1 knockout vertebrate model recapitulates the human clinical phenotypes, confirms variant pathogenicity, and uncovers evidence implicating the p.Met1? variant as potentially impacting an exon critical for normal hearing. Together, our findings provide consolidating evidence for biallelic disruption of WARS1 as causal for an autosomal recessive neurodevelopmental syndrome and present a vertebrate model that recapitulates key phenotypes observed in patients.
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대학원 (응용생명과학부)
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