Anti-helicobacter pylori activity of compounds isolated from fraxinus mandshurica bark
- Akter, K.-M.; Kim, H.-J.; Park, W.S.; Khalil, A.A.K.; Ahn, M.-J.
- Issue Date
- Korean Society of Pharmacognosy
- Anti-Helicobacter pylori; Calceolarioside A; Calceolarioside B; Fraxetin; Fraxinus mandshurica
- Natural Product Sciences, v.26, no.2, pp.158 - 164
- Journal Title
- Natural Product Sciences
- Start Page
- End Page
- Helicobacter pylori is a well-known pathogen that is responsible for gastric disorders. Overcoming of the antibiotic-resistance is a main barrier to treat H. pylori infection. In our search for anti-H. pylori compounds from natural resources, bioactivity-guided isolation on the ethyl acetate fraction of Fraxinus mandshurica bark that had shown anti-H. pylori activity gave twelve compounds (1-12) of six coumarins, three phenylethanoids, two secoiridoids, and a lignan using silica gel column chromatography, Sephadex-LH 20, and recrystallization. The chemical structures were identified by spectroscopic data analysis, including 1D, 2D NMR, and mass spectrometry. Among them, compounds 2, 10, and 11 showed moderate growth inhibitory activity against three strains of H. pylori, compared with positive controls of quercetin and metronidazole. Compounds 5, 6, 8, and 12 exhibited the inhibitory activity against strains 26695 or 43504. This is the first report on the anti-H. pylori activity of this plant and the isolated compounds. ? 2020, Korean Society of Pharmacognosy. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 약학대학 > 약학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.