Iron oxide nanoparticles-loaded hydrogels for effective topical photothermal treatment of skin cancerIron oxide nanoparticles-loaded hydrogels for effective topical photothermal treatment of skin cancer
- Other Titles
- Iron oxide nanoparticles-loaded hydrogels for effective topical photothermal treatment of skin cancer
- Authors
- Amatya, Reeju; Kim, Doyeon; Min, Kyoung Ah; Shin, Meong Cheol
- Issue Date
- Nov-2022
- Publisher
- SPRINGERNATURE
- Keywords
- Iron oxide nanoparticles; Hydrogel; Photothermal therapy; Cancer; Topical application
- Citation
- JOURNAL OF PHARMACEUTICAL INVESTIGATION, v.52, no.6, pp.775 - 785
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF PHARMACEUTICAL INVESTIGATION
- Volume
- 52
- Number
- 6
- Start Page
- 775
- End Page
- 785
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/804
- DOI
- 10.1007/s40005-022-00593-9
- ISSN
- 2093-5552
- Abstract
- Purpose A hydrogel containing dextran-coated iron oxide nanoparticles (DEX-IONP) was developed, and its applicability in topical photothermal therapy (PTT) of skin cancer was explored in vitro and in vivo. Methods DEX-IONP carbopol hydrogel was prepared by adopting the pH-triggered in situ gel-forming method. After preparation, physical characteristics and the photothermal activities of the DEX-IONP gel were evaluated in vitro in varying DEX-IONP concentrations. The photothermal activity was further examined in B16F10 s.c. tumor-bearing mice. Lastly, the efficacy of DEX-IONP gel-based topical PTT was evaluated in vivo. Results The prepared DEX-IONP gel retained high viscosity favorable to maintain at the applied site. In addition, the DEX-IONP gel could induce effective heating by laser irradiation. The cellular and in vivo studies evidenced the applicability of DEX-IONP in topical PTT. Finally, the preliminary efficacy study results in the B16F10 s.c. mice model demonstrated that tumor volumes could be significantly reduced by the topical PTT with DEX-IONP gel. Notably, by a single PTT treatment with 100 mu gFe/mL DEX-IONP gel and applying 0.5 W laser power for 10 min, the tumor growth could be significantly inhibited by 85%. Conclusion Overall, our results demonstrate that DEX-IONP gels may serve as an effective topical PTT agent.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/804)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.