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Anti-inflammatory effects of extract from <i>Haliotis discus hannai</i> fermented with <i>Cordyceps militaris</i> mycelia in RAW264.7 macrophages through TRIF-dependent signaling pathway
- Authors
- Joung, Hong-Joo; Kim, Yon-Suk; Hwang, Jin-Woo; Han, Young-Ki; Jeong, Jae-Hyun; Lee, Jung-Suck; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam
- Issue Date
- May-2014
- Publisher
- Academic Press
- Keywords
- Haliotis discus hannai; Cordyceps militaris; Fermentation; Anti-inflammatory
- Citation
- Fish and Shellfish Immunology, v.38, no.1, pp 184 - 189
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Fish and Shellfish Immunology
- Volume
- 38
- Number
- 1
- Start Page
- 184
- End Page
- 189
- ISSN
- 1050-4648
1095-9947
- Abstract
- In this study, Haliotis discus hannai (H. discus hannai) fermentation was attempted with Cordyceps milltaris (C. militaris) mycelia using a solid culture. We tried to ferment H. discus hannai to determine the optimal conditions fermentation with regards to its anti-inflammatory effects. The extracts of H. discus hannai fermented with C militaris mycelia (HFCM-5) showed higher nitric oxide inhibitory effects than H. discus hannai and C militaris alone. HFCM-5 also decreased pro-inflammatory cytokines, TNF-alpha and IL-6 in a dose-dependent manner. HFCM-5 did not affect the MyD88-dependent pathway, but decreased phosphorylation of IRF3 and STAT1 which are involved in TRIF-dependent pathway. Taken together, our results suggest that HFCM-5 exerts its anti-inflammatory effects via TRIF signaling pathway and could potentially be used as a functional food in the regulation of inflammation. (c) 2014 Elsevier Ltd. All rights reserved.
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