해당화 추출물의 미세먼지로 유도된 피부 손상 및 노화 억제 효과

Abstract

In recent years, Rosa rugosa has gained recognition as a source of antioxidant phytochemical owing to its abundant phenolic compounds and potent antioxidant activities. However, its protective effects against damage from particulate matter (PM) remain unreported. Therefore, this study focused on the protective effects of R. rugosa ethanol extract (REE) in PM-induced human dermal fibroblasts (HDFs). REE exerted a strong inhibitory effect against DPPH radicals and hydrogen peroxide. It also suppressed the expression of proinflammatory cytokines and matrix metalloproteinases-10 (MMP-10) and promoted collagen synthesis in PM-induced HDFs. Furthermore, the protein expression level of the cell senescence-related marker p53 was reduced in PM-induced HDFs. Furthermore, REE significantly inhibited intracellular reactive oxygen species generation in a PM-treated in vivo zebrafish model, with no observed morphological toxicity. Altogether, these results indicate that REE can be used as a skin antiaging cosmeceutical by suppressing PM-induced collagen degradation and inflammatory responses.