Clinical Experiences Using CyberKnife for Large-Volume Meningiomas: A Preliminary Study

Abstract

"Background: This preliminary study evaluates the safety and efficacy of CyberKnife radiosurgery (CKRS) for large-volume meningiomas (≥10 cm3 ), where surgical options may be limited due to tumor location or patient health conditions. Methods: We retrospectively analyzed 18 patients with meningiomas treated with CKRS at Gyeongsang National University Hospital between 2010 and 2020. Tumor control and survival rates were evaluated, with follow-up imaging performed regularly. Results: CKRS achieved a 5-year overall survival rate of 92.3% and a 5-year tumor control rate of 93.8%. Symptomatic peritumoral edema occurred in 61.1% of patients, with 16.7% requiring surgical intervention. Conclusion: CKRS appears to be a promising option for patients with large meningiomas, show ing good tumor control and manageable complications. Further studies with larger cohorts are neces sary to confirm these findings"