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Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in miceopen access
- Authors
- Kim, Mi Jeong; Choi, Soo Jung; Lim, Seung-Taik; Kim, Hye Kyung; Heo, Ho Jin; Kim, Eun-Ki; Jun, Woo Jin; Cho, Hong Yon; Kim, Young Jun; Shin, Dong-Hoon
- Issue Date
- Apr-2007
- Publisher
- Japan Society for Bioscience Biotechnology and Agrochemistry/Nippon Nogeikagaku Kai
- Keywords
- Choline acetyltransferase; Cognitive function; Ferulic acid (4-hydroxy-3-methoxycinnamic acid); Trimethyltin
- Citation
- Bioscience, Biotechnology and Biochemistry, v.71, no.4, pp 1063 - 1068
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Bioscience, Biotechnology and Biochemistry
- Volume
- 71
- Number
- 4
- Start Page
- 1063
- End Page
- 1068
- ISSN
- 0916-8451
1347-6947
- Abstract
- This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.
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