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참돔(Pagrus major)에서 분리된 CD74a의 분자적 특징과 병원체별 발현 분석Analysis of Molecular Characteristics and Pathogen Expression of CD74a Isolated from Red sea bream (Pagrus major)
- Other Titles
- Analysis of Molecular Characteristics and Pathogen Expression of CD74a Isolated from Red sea bream (Pagrus major)
- Issue Date
- Dec-2020
- Publisher
- 한국수산해양교육학회
- Keywords
- MHC class II; Red sea bream; Invariant chain; CD74a
- Citation
- 수산해양교육연구, v.32, no.6, pp 1391 - 1400
- Pages
- 10
- Indexed
- KCI
- Journal Title
- 수산해양교육연구
- Volume
- 32
- Number
- 6
- Start Page
- 1391
- End Page
- 1400
- ISSN
- 1229-8999
2288-2049
- Abstract
- When pathogens invade fish, MHC class II and CD74 bind to the Golgi apparatus of antigen-presenting cells and are transcribed, causing an immune response. Through NGS analysis, the molecular characteristics and tissue-specific expression of PmCD74a identified in red sea bream were confirmed. As a result, PmCD74a showed high expression in the gills and intestines, and showed downward expression after pathogen infection, and then upward expression. The results of this study suggest that CD74a will play an important role in the immune process of red sea bream.
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