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Dopa Responsive Parkinsonism in an Early Onset Alzheimer's Disease Patient with a Presenilin 1 Mutation (A434T)
- Authors
- Jo, Hyunjin; Kim, Minkyeong; Park, Seongbeom; Park, Jong Eun; Cho, Soo Hyun; Kim, Seung Joo; Jang, Hyemin; Jung, Yong Hee; Kim, Junpyo; Na, Duk L.; Seo, Sang Won; Cho, Jin Whan; Kim, Hee Jin
- Issue Date
- Sep-2019
- Publisher
- IOS PRESS
- Keywords
- Alzheimer's disease; FP-CIT PET; L-dopa; parkinsonism; presenilin 1
- Citation
- JOURNAL OF ALZHEIMERS DISEASE, v.71, no.1, pp 7 - 13
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ALZHEIMERS DISEASE
- Volume
- 71
- Number
- 1
- Start Page
- 7
- End Page
- 13
- ISSN
- 1387-2877
1875-8908
- Abstract
- Alzheimer's disease patients with presenilin 1 (PSEN1) mutations commonly show parkinsonism in addition to dementia. Yet, whether these patients show dopaminergic deficit and response to L-dopa is largely unknown. We report a 43-year-old woman with a PSEN1 mutation (A434T) who showed right side dominant parkinsonism. As disease progressed, she developed bilateral parkinsonism which was markedly relieved by L-dopa. Amyloid (Florbetaben) positron-emission tomography (PET) showed cortical florbetaben uptake, relatively sparing the striatum. Initial dopamine transporter (FP-CIT) PET showed asymmetrically decreased FP-CIT uptake in the left striatum. We suggest that in Alzheimer's disease patients with PSEN1 mutation, parkinsonism may be relieved by L-dopa when it is associated with presynaptic dopaminergic deficit.
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