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The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Diseaseopen access
- Authors
- Kim, Hyun Kuk; Tantry, Udaya S.; Smith, Sidney C., Jr.; Jeong, Myung Ho; Park, Seung-Jung; Kim, Moo Hyun; Lim, Do-Sun; Shin, Eun-Seok; Park, Duk-Woo; Huo, Yong; Chen, Shao-Liang; Bo, Zheng; Goto, Shinya; Kimura, Takeshi; Yasuda, Satoshi; Chen, Wen-Jone; Chan, Mark; Aradi, Daniel; Geisler, Tobias; Gorog, Diana A.; Sibbing, Dirk; Lip, Gregory Y. H.; Angiolillo, Dominick J.; Gurbel, Paul A.; Jeong, Young-Hoon
- Issue Date
- Apr-2021
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- race; antiplatelet therapy; direct oral anticoagulants; ischemic risk; bleeding risk
- Citation
- THROMBOSIS AND HAEMOSTASIS, v.121, no.04, pp 422 - 432
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- THROMBOSIS AND HAEMOSTASIS
- Volume
- 121
- Number
- 04
- Start Page
- 422
- End Page
- 432
- ISSN
- 0340-6245
2567-689X
- Abstract
- East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y (12) receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.
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