한국 성인의 대사 위험인자 패턴 및 영양상태와 심뇌혈관질환 또는 지방간 발생 위험률: 전향적 코호트 연구

Abstract

Objectives: To determine the nutrient intake according to patterns of metabolic risk factors, and examine the relationship between patterns of meta- bolic risk factors and incidence of cardiocerebrovascular disease or fatty liver in Korean adults. Methods: Data from the Korean Genome and Epidemiol- ogy Study were used to analyze 7,019 adults aged 50-64 years old. Depending on patterns of metabolic risk factors, participants were classified into four categories: ‘normal, NOR’, ‘obesity risk factors, ORF’ , ‘vascular risk factors, VRF’, ‘cluster risk factors, CRF’. Cox regression analysis was used to evaluate the incidence of cardiocerebrovascular disease or fatty liver. Results: The mean adequacy ratio (MAR) of VRF pattern women was significantly lower than that of the normal women. In Model 3, the incidence of cardiovascular disease or fatty liver decreased by 64.4% (hazard ratio (HR), 0.36; 95% confidence interval (CI), 0.15-0.84) in MAR Q3 women compared to MAR Q1 women. In Model 2 adjusted for age and energy intake, the incidence of cardiovascular disease or fatty liver increased by 87.6% (HR, 1.88; 95% CI, 1.01-3.48) in CRF pattern women compared to NOR women, but there was no significant dif- ference in Model 3. Conclusions: The study showed that among women, VRF patterns were associated with poor nutrient intake. There was an associa- tion between nutrient intake levels and metabolic risk factor patterns in women. Therefore, these findings can be used a basis to emphasize the need to establish nutrition management strategies tailored to individual’s metabolic risk status, for the prevention and management of metabolic syndrome complications.