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Drug-induced nephrotoxicityopen access
- Authors
- Bae, Eunjin; Lee, Tae Won; Park, Dong Jun
- Issue Date
- Jan-2020
- Publisher
- KOREAN MEDICAL ASSOC
- Keywords
- Glomerulus; Kidney tubules; Renal insufficiency; Pharmaceutical preparations; Toxicity
- Citation
- JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, v.63, no.1, pp 30 - 35
- Pages
- 6
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
- Volume
- 63
- Number
- 1
- Start Page
- 30
- End Page
- 35
- ISSN
- 1975-8456
2093-5951
- Abstract
- Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and tends to increase among certain patients and/or with complex clinical conditions. Unfortunately, apart from conservative management, including drug withdrawal, no effective treatment is known for this condition. Therefore, in order to reduce the frequency of drug-induced nephrotoxicity, early recognition of renal toxicity and appropriate prevention strategies, such as understanding the exact mechanisms of renal injury, patient and drug-related risk factors, and preemptive measures are needed. In this review, we will present the mechanisms of drug-induced nephrotoxicity and general preventive strategies for clinical physicians.
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