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AMPK 활성화를 통한 중금속 유발 산화적 스트레스에 대한 비파엽의 세포 보호 효과Cytoprotective effect of Eriobotrya japonica L. against the iron-induced oxidative stress through AMPK activation
- Other Titles
- Cytoprotective effect of Eriobotrya japonica L. against the iron-induced oxidative stress through AMPK activation
- Issue Date
- Feb-2024
- Publisher
- 대한한의학방제학회
- Keywords
- Eriobotrya japonica L.; oxidative stress; AMPK; hepatocyte
- Citation
- 대한한의학 방제학회지, v.32, no.1, pp 99 - 109
- Pages
- 11
- Indexed
- KCI
- Journal Title
- 대한한의학 방제학회지
- Volume
- 32
- Number
- 1
- Start Page
- 99
- End Page
- 109
- ISSN
- 1229-1218
2288-5641
- Abstract
- Objectives : In this study, we investigated the cytoprotective effect of Eriobotrya japonica L. (EJ) extract against Arachidonic acid (AA)+iron-induced oxidative stress. Methods : To confirm the cytoprotective effect of EJ against AA+iron-induced oxidative stress in HepG2 cells, it was evaluated by MTT assay, immunoblot anaylsis, and Calcein-AM/propidium iodide (PI) staining. Additionally, the mechanism of action of the cytoprotective effect was evaluated through molecular mechanisms. Results : EJ (100 μg/mL) inhibited Arachidonic acid (AA)+iron-induced cell death in a concentration-dependent manner. It also inhibited AA+iron-induced mitochondrial dysfunction and ROS production. EJ activated the LKB1-AMPK signaling pathway. Conclusions : In conclusion, EJ has the ability to protect liver cells from oxidative stress, indicating that it is related to AMPK-LKB1 signaling pathways.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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