새싹인삼 추출물의 항산화 활성 및 MMP-1 저해 활성Antioxidant activity and MMP-1 inhibitory activity of Panax Ginseng Sprout Extracts
- Other Titles
- Antioxidant activity and MMP-1 inhibitory activity of Panax Ginseng Sprout Extracts
- Authors
- 김민정; 양예진; 양주혜; 이원융; 김우현; 이재남; 박광일
- Issue Date
- Feb-2024
- Publisher
- 대한한의학방제학회
- Keywords
- Panax Ginseng Sprout; Fermentation; Anti-oxidation; MMP-1; Skin Aging
- Citation
- 대한한의학 방제학회지, v.32, no.1, pp 83 - 90
- Pages
- 8
- Indexed
- KCI
- Journal Title
- 대한한의학 방제학회지
- Volume
- 32
- Number
- 1
- Start Page
- 83
- End Page
- 90
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/70343
- ISSN
- 1229-1218
2288-5641
- Abstract
- Objectives : As a substitute for high-price ginseng, this study attempted to examine a possibility of the ferment extract of Panax ginseng sprout whether leaves and roots can be used together as a cosmetic ingredient with anti-oxidative and wrinkle-care effects.
Methods : In terms of a test method, antioxidant activities were confirmed through total polyphenol contents, total flavonoid contents, DPPH radical scavenging activity and ABTS radical scavenging activity using the Panax ginseng sprout. In addition, to assess wrinkle-care effectiveness, the cytotoxicity of the extract was analyzed through MTT assay, and inhibition of collagenase activity in the cells was tested using the Panax ginseng sprout fermented by Saccharomyces cerevisiae.
Resuits : The content of polyphenols and flavonoids in natural plants was highest in Panax Ginseng Sprout Extract at 100℃, which also demonstrated high DPPH, ABTS radical scavenging activity. MTT assay demonstrated that the Panax Ginseng Sprout Ferment Extract did not have a cytotoxic effect in CCD-986SK cell. Also, Panax Ginseng Sprout Ferment Extract was found to inhibit MMP-1 expression by 51.85±6.09% at a concentration of 10%.
Conclusions : Therefore, this study has confirmed a possibility of Panax ginseng sprout ferment extract as a cosmetic ingredient with MMP-1-inhibitory effects.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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