Monitoring and evaluation of provincial classical swine fever immunization implementation with an E2 subunit vaccine in Jeju Island, South Koreaopen access
- Authors
- Jang, Guehwan; Kim, Eun-Joo; Cho, Seong-Cheol; Moon, Sung-Up; Lee, Myeong Hwa; Ko, Jin A.; Ko, Seung Bo; Lee, Jonghoo; Lee, Changhee
- Issue Date
- Jan-2024
- Publisher
- Korean Vaccine Society
- Keywords
- Classical swine fever virus; CSF-E2 subunit vaccine; Herd immunity stabilization; Jeju Island; Provincial vaccination
- Citation
- Clinical and Experimental Vaccine Research, v.13, no.1, pp 54 - 62
- Pages
- 9
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Clinical and Experimental Vaccine Research
- Volume
- 13
- Number
- 1
- Start Page
- 54
- End Page
- 62
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/69955
- DOI
- 10.7774/cevr.2024.13.1.54
- ISSN
- 2287-3651
2287-366X
- Abstract
- Purpose: Accidental vaccination with a live attenuated low-virulence strain of Miyagi (LOM) vaccine led to the reemergence of classical swine fever virus (CSFV) in Jeju province, South Korea in 2014. To control the continual outbreaks of LOM-derived CSFV, the provincial government launched a provincial mass vaccination project using a CSF-E2 subunit vaccine. We conducted this study to assess the herd immunity level and outcomes of E2 vaccine-based immunization in breeding and growing herds on Jeju Island during 2020–2021. Materials and Methods: A large-scale vaccination trial using the Bayovac CSF-E2 vaccine investigated its efficacy in breeding and growing herds under farm application conditions (10 CSFV-affected and three CSFV-naïve swine farms). Results: The level of herd immunity in each farm was classified into three (S1–S3) and six (G1–G6) profiles in breeding and growing herds, respectively. Immunity monitoring revealed a remarkable improvement in the herd immunity status in all farms. The majority (10/13) of farms, including CSFV-free farms, showed the S1G1 immunity profile in 2021, indicating the ap-propriate implementation of the advised vaccination regime. Moreover, there were significant decreases in Erns seropositivity from 100% to 50% and 25.9% to 4.3% at farm and pig levels, re-spectively. In particular, all farms were confirmed as CSFV free in the growing-finishing herds. Conclusion: Our large-scale trial demonstrated the effectiveness of the E2 subunit vaccine in establishing herd immunity stabilization and eliminating CSFV circulation in the affected farms and highlighted the need for a provincial vaccination policy to regain the CSF-free status on Jeju Island. © Korean Vaccine Society.
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