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Isoflavone-enriched soybean leaves (Glycine max) restore loss of dermal collagen fibers induced by ovariectomy in the Sprague Dawley ratsopen accessIsoflavone-enriched soybean leaves (Glycine max) restore loss of dermal collagen fibers induced by ovariectomy in the Sprague Dawley rats

Other Titles
Isoflavone-enriched soybean leaves (Glycine max) restore loss of dermal collagen fibers induced by ovariectomy in the Sprague Dawley rats
Authors
Yoo, Dae YoungXie, Cheng-liangJeong, Joo YeonPark, Ki HunKang, Sang SooLee, Dong Hoon
Issue Date
Feb-2024
Publisher
SPRINGERNATURE
Keywords
Isoflavone; Soybean leaves; Collagen; Skin; Menopause; Ovariectomy
Citation
LABORATORY ANIMAL RESEARCH, v.40, no.1, pp 115 - 120
Pages
6
Indexed
ESCI
KCI
Journal Title
LABORATORY ANIMAL RESEARCH
Volume
40
Number
1
Start Page
115
End Page
120
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69735
DOI
10.1186/s42826-024-00189-4
ISSN
1738-6055
2233-7660
Abstract
Phytoestrogens, such as isoflavones, are known for their capacity to simulate various physiological impacts of estrogen in the human body. Our research evaluated the effects of isoflavone-enriched soybean leaves (IESL) on collagen fiber loss prompted by ovariectomy in Sprague Dawley (SD) rats, thereby simulating menopausal changes in women. IESL, bolstered with an increased concentration of isoflavones through a metabolite farming process, contained a significantly higher amount of isoflavones than regular soybean leaves. Our results indicate that the administration of IESL can counteract the decrease in relative optical density and dermal thickness of collagen fibers caused by ovariectomy in SD rats, with more pronounced effects observed at higher isoflavone dosages. These outcomes suggest that soybean leaves rich in isoflavones may hold potential benefits in combating collagen degradation and skin aging symptoms related to menopause. Further research is needed to fully understand the exact molecular pathways at play and the potential clinical relevance of these findings.
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