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BMP-2-immobilized PCL 3D printing scaffold with a leaf-stacked structure as a physically and biologically activated bone graft

Authors
Kim, Min JiPark, Jin-HoSeok, Ji MinJung, JiwoonHwang, Tae SungLee, Hee-ChunLee, Jin HoPark, Su A.Byun, June HoOh, Se Heang
Issue Date
Apr-2024
Publisher
IOP Publishing Ltd
Keywords
3D printing; bone morphogenetic protein-2 (BMP-2); bone reconstruction; leaf-stacked structure; tissue engineering
Citation
Biofabrication, v.16, no.2
Indexed
SCIE
SCOPUS
Journal Title
Biofabrication
Volume
16
Number
2
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69718
DOI
10.1088/1758-5090/ad2537
ISSN
1758-5082
1758-5090
Abstract
Although three-dimensional (3D) printing techniques are used to mimic macro- and micro-structures as well as multi-structural human tissues in tissue engineering, efficient target tissue regeneration requires bioactive 3D printing scaffolds. In this study, we developed a bone morphogenetic protein-2 (BMP-2)-immobilized polycaprolactone (PCL) 3D printing scaffold with leaf-stacked structure (LSS) (3D-PLSS-BMP) as a bioactive patient-tailored bone graft. The unique LSS was introduced on the strand surface of the scaffold via heating/cooling in tetraglycol without significant deterioration in physical properties. The BMP-2 adsorbed on3D-PLSS-BMPwas continuously released from LSS over a period of 32 d. The LSS can be a microtopographical cue for improved focal cell adhesion, proliferation, and osteogenic differentiation.In vitrocell culture andin vivoanimal studies demonstrated the biological (bioactive BMP-2) and physical (microrough structure) mechanisms of3D-PLSS-BMPfor accelerated bone regeneration. Thus, bioactive molecule-immobilized 3D printing scaffold with LSS represents a promising physically and biologically activated bone graft as well as an advanced tool for widespread application in clinical and research fields. © 2024 IOP Publishing Ltd.
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