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Host Subcellular Organelles: Targets of Viral Manipulationopen access

Authors
Song, Min SeokLee, Dong-KunLee, Chung-YoungPark, Sang-CheolYang, Jinsung
Issue Date
Feb-2024
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
endocytosis; endoplasmic reticulum; infection; lysosome; membrane; organelles; virus
Citation
International Journal of Molecular Sciences, v.25, no.3
Indexed
SCIE
SCOPUS
Journal Title
International Journal of Molecular Sciences
Volume
25
Number
3
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69684
DOI
10.3390/ijms25031638
ISSN
1661-6596
1422-0067
Abstract
Viruses have evolved sophisticated mechanisms to manipulate host cell processes and utilize intracellular organelles to facilitate their replication. These complex interactions between viruses and cellular organelles allow them to hijack the cellular machinery and impair homeostasis. Moreover, viral infection alters the cell membrane’s structure and composition and induces vesicle formation to facilitate intracellular trafficking of viral components. However, the research focus has predominantly been on the immune response elicited by viruses, often overlooking the significant alterations that viruses induce in cellular organelles. Gaining a deeper understanding of these virus-induced cellular changes is crucial for elucidating the full life cycle of viruses and developing potent antiviral therapies. Exploring virus-induced cellular changes could substantially improve our understanding of viral infection mechanisms. © 2024 by the authors.
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