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The prognostic impact of body mass index in breast cancer according to tumor subtypeopen accessThe prognostic impact of body mass index in breast cancer according to tumor subtype

Other Titles
The prognostic impact of body mass index in breast cancer according to tumor subtype
Authors
Kim Jae-MyungKim Ju-YeonJung Eun JungKwag Seung-JinPark Ji-HoCho Jin KyuKim Han-GilJeong Chi-YoungJu Young-TaeLee Young-Joon
Issue Date
Dec-2023
Publisher
대한종양외과학회
Keywords
Breast neoplasms; Body mass index; Neoplasm metastasis; Locoregional neoplasm recurrence
Citation
대한종양외과학회지, v.19, no.2, pp 52 - 59
Pages
8
Indexed
KCI
Journal Title
대한종양외과학회지
Volume
19
Number
2
Start Page
52
End Page
59
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69654
DOI
10.14216/kjco.23010
ISSN
2288-4084
Abstract
Purpose: Several studies demonstrated that obesity and underweight were negatively associated with outcomes of breast cancer. However, the results are still controversial, and the impact of body mass index (BMI) on distant metastasis-free survival (MFS), which might directly affect mortality, was less well evaluated. Our study aimed to verify the prognostic effect of BMI in breast cancer.Methods: A retrospective analysis of 504 patients with stage I-III breast cancer who underwent surgery from January 2005 to December 2013 was performed. The patients were divided into three groups according to preoperative BMI: underweight <18.5 kg/m<sup>2</sup>, normal weight 18.5–24.9 kg/m<sup>2</sup>, and overweight ≥25 kg/m<sup>2</sup>. The association between body weight status and breast cancer recurrence was analyzed. Subgroup analysis by tumor subtype according to receptor status was also performed.Results: The median follow-up period was 88 months. For disease recurrence, histologic grade and human epidermal growth factor receptor 2 (HER2)-positivity were independent prognostic factors in multivariate analysis. Stage, histologic grade, HER2-positivity, and BMI status were independent prognostic factors for distant metastasis. In survival analysis, overweight and underweight were significant predisposing factors for MFS, but not for disease-free survival (DFS). In the estrogen receptor (ER)-positive group, overweight and underweight patients had significantly worse DFS and MFS than normal weight patients. In the ER-negative or HER2-positive group, BMI status had no significant association with DFS and MFS.Conclusion: The prognostic role of BMI on the survival outcomes of patients with breast cancer was different by tumor subtype. In ER-positive patients, overweight and underweight statuses had a negative prognostic effect on DFS and MFS, respectively.
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