Multi-tissue transcriptome analysis to identify candidate genes associated with weight regulation in Hanwoo cattleopen access
- Authors
- Jang, Subin; Jang, Sunsik; Kim, Jaemin; Park, Woncheoul
- Issue Date
- Jan-2024
- Publisher
- Frontiers Media SA
- Keywords
- body weight; differentially expressed genes; eQTL analysis; Hanwoo; transcriptome
- Citation
- Frontiers in Genetics, v.14
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Genetics
- Volume
- 14
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/69498
- DOI
- 10.3389/fgene.2023.1304638
- ISSN
- 1664-8021
1664-8021
- Abstract
- While genetic markers related to meat production traits have been identified in many other cattle breeds, research on weight in Hanwoo cattle (Korean native cattle) is still insufficient. In this study, we performed expression quantitative trait loci (eQTL) analysis and differential gene expression analysis to detect candidate genes influencing the weight characteristics of 32 castrated Hanwoo cattle across 22 tissues and, we identified variants that affect gene expression levels. In total, we identified a total of 3,298 differentially expressed genes, among which we discovered key genes such as UBD, RGS2, FASN, and SCD that have functions related to adipogenesis, body weight, obesity, and lipid metabolism. Gene-set enrichment analysis revealed that candidate genes in adipose tissue are involved in metabolic pathways linked to obesity-related traits, adipose metabolism, and lipid metabolism. Additionally, we found that decreased expression of TRIM31 contributes to weight gain which can be explained by the associated candidate cis-eQTL genotypes for TRIM31 and their effect on differential gene expression between the lower and higher weight groups. Our findings revealed candidate genes associated with the weight of Hanwoo cattle and perhaps can provide comprehensive insights into the association of weight with various tissues beyond adipose tissue and muscle, indicating the potential for expanding the focus of livestock trait research. Copyright © 2024 Jang, Jang, Kim and Park.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/69498)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.