Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Comparative study on silver nanoparticles adsorption by ultrasonication and hydrothermal approaches on β-cyclodextrin incorporated polyurethane micro-nanofibers as multifunctional tissue engineering candidate

Authors
Khan, Rumysa SaleemRather, Anjum HamidWani, Taha UmairRafiq, MuheebEl Hassan, Somia Abd Alla MohammedAmna, TouseefRather, Sami-ullahJadhav, Arvind H.Ahmad, Syed MudasirSheikh, Faheem A.
Issue Date
Feb-2024
Publisher
Elsevier B.V.
Keywords
Fiber; Hydrophilicity; Hydrothermal; Tissue engineering; Ultrasonication
Citation
Progress in Organic Coatings, v.187
Indexed
SCOPUS
Journal Title
Progress in Organic Coatings
Volume
187
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69430
DOI
10.1016/j.porgcoat.2023.108144
ISSN
0300-9440
1873-331X
Abstract
For an efficient tissue-engineered implant, it is mandatory to have appropriate fluid absorption and antibacterial properties. In this regard, polyurethane micro-nanofibers were modified by incorporating β-cyclodextrin by electrospinning and then adsorbed using silver (Ag) nanoparticles (NPs). We selected the adsorption by ultrasonication and hydrothermal methods and compared results for hydrophilicity, biodegradation, biocompatibility, and antibacterial activity. Scanning electron microscopy confirmed fiber diameter in mats with hydrothermally adsorbed Ag NPs was 8.0 ± 2.2 μm, and that of ultrasonically adsorbed Ag NPs was 4.0 ± 1.7 μm. The hydrophilicity results showed that incorporation of β-cyclodextrin in mats led to the decrease in water angle, and the Ag NPs adsorbed mats measured 53.50 ± 0.1° and 55.18 ± 0.15° at 1 min. The Ag NPs release by UV–visible spectroscopy indicated higher release in the case of ultrasonically adsorbed Ag NPs. Ultrasonically adsorbed Ag NPs showed higher antibacterial activity than hydrothermally against Staphylococcus aureus and Escherichia coli with 15 ± 2 mm and 12 ± 1 mm clear zones. The mouse fibroblasts showed a viability of >100 % in all mats, which determined that the fibers were biocompatible. The highest viability was seen in ultrasonically adsorbed Ag NP mats (262.76 ± 11.24 %). The cell attachment studies showed well-spread cells, concluding with excellent biocompatibility. Overall, results indicate ultrasonic adsorption is a straightforward and better strategy than hydrothermal treatment. © 2023 Elsevier B.V.
Files in This Item
There are no files associated with this item.
Appears in
Collections
ETC > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE