Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantationopen access

Authors
Lim, SubinHong, Soon JunKim, Ju HyeonCha, Jung-JoonJoo, Hyung JoonPark, Jae HyoungYu, Cheol WoongKim, Byeong-KeukChang, KiyukPark, YongwhiSong, Young BinAhn, Sung GyunSuh, Jung-WonLee, Sang YeubCho, Jung RaeHer, Ae-YoungJeong, Young-HoonKim, Hyo-SooKim, Moo HyunShin, Eun-SeokLim, Do-SunKim, Hyun KukLee, Jung HeeLee, Byoung KwonKim, WeonPark, Kyung WooMoon, Jae YeonKwon, OsungKim, Chan JoonPark, Hyun-WoongLee, Chang HoonJang, Woo JinJin, Han-YoungChon, Min KuChoi, Ki HongHan, Dong HoonKang, Min GyuKang, JeehoonKi, You JeongPark, Jin SupLee, Seung-JunLee, Seung HunLee, Jong-YoungCho, Sung WonSuh, JonBae, Jang-WhanYou, Seng ChanLim, Do-SunJeong, Myung Ho
Issue Date
Jan-2024
Publisher
Nature Research
Citation
Scientific Reports, v.14, no.1
Indexed
SCOPUS
Journal Title
Scientific Reports
Volume
14
Number
1
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69428
DOI
10.1038/s41598-023-50920-9
ISSN
2045-2322
Abstract
Stent thrombosis (ST) is a fatal complication after percutaneous coronary intervention (PCI). The association between P2Y12 reaction unit (PRU) level and stent thrombosis occurrence remains unclear. Based on the multicenter, observational PTRG-DES (Platelet function and genoType-Related long-term proGnosis in DES-treated patients) registry of patients with drug-eluting stents (DES) implantation, a total of 11,714 patients with PRU values were analyzed. We sought to identify the predictors of early stent thrombosis (EST) and compared the primary outcome, a composite of cardiac death, myocardial infarction, and revascularization, between EST and non-EST groups. EST, defined as definite ST within 1 month after index PCI, occurred in 51 patients. PRU values were significantly higher in the EST group (263.5 ± 70.8 vs. 217.5 ± 78.7, p < 0.001). In multivariable analysis, PRU ≥ 252 (OR, 5.10; 95% CI 1.58–16.46; p = 0.006) and aspirin reaction unit ≥ 414 (OR 4.85; 95% CI 1.07–21.97; p = 0.040) were independent predictors of EST. The cumulative incidence of primary composite outcome at one year was significantly higher in the EST group (38.2% vs. 3.9%, Log-rank p < 0.001). In patients treated with clopidogrel after successful DES implantation, EST was associated with higher platelet reactivities, and a greater risk of cardiovascular events. Trial Registration: clinicaltrials.gov Identifier: NCT04734028. © 2024, The Author(s).
Files in This Item
There are no files associated with this item.
Appears in
Collections
ETC > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE