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Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model

Authors
Park, WonhyoungKim, MijiKim, Hee SeungSong, GwonhwaPark, Soo JinLim, WhasunPark, Sunwoo
Issue Date
Jan-2024
Publisher
SPRINGER HEIDELBERG
Keywords
Endometriosis; Fecundity; Pregnancy experience; Pregnancy
Citation
REPRODUCTIVE SCIENCES
Indexed
SCOPUS
Journal Title
REPRODUCTIVE SCIENCES
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/69341
DOI
10.1007/s43032-023-01426-2
ISSN
1933-7191
1933-7205
Abstract
This study is aimed at identifying variations in the effect of endometriosis on fecundity in a mouse model based on prior pregnancy experience. Endometriosis is one of the most prevalent gynecological diseases and is known to impact female fecundity adversely. In this study, an endometriosis mouse model was established by allografting uterine horn tissue using Pelch's method. The effect of endometriosis on fecundity was confirmed in primiparous and multiparous female mice. As fecundity indicators, the pregnancy rate, number of litters, pregnancy period, and survival rate of the pups were investigated. As a result of the experiment, the pregnancy rate decreased, and the pregnancy period tended to be shorter in primiparous female mice. However, there was no significant change in the multiparous mice. In addition, it has been established that correlations exist between the size of lesions and certain fecundity indicators of the lesion, even among primiparous and multiparous females with endometriosis. The study attempted to demonstrate a link between pregnancy experience and fecundity changes caused by endometriosis by experimentally reproducing clinical results using mouse models. These results suggest strategies for identifying several pathophysiological characteristics of endometriosis.
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Park, Sun Woo
자연과학대학 (항노화신소재과학과)
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