Designing Highly Aligned Cultured Meat with Nanopatterns-Assisted Bio-Printed Fat ScaffoldsDesigning Highly Aligned Cultured Meat with Nanopatterns-Assisted Bio-Printed Fat Scaffolds
- Other Titles
- Designing Highly Aligned Cultured Meat with Nanopatterns-Assisted Bio-Printed Fat Scaffolds
- Authors
- Park, Sangbae; Hong, Yeonggeol; Park, Sunho; Kim, Woochan; Gwon, Yonghyun; Jang, Kyoung-Je; Kim, Jangho
- Issue Date
- Dec-2023
- Publisher
- Springer Nature
- Keywords
- 3D printing; Cultured meat; Fat scaffold; Nanopattern
- Citation
- Journal of Biosystems Engineering, v.48, no.4, pp 503 - 511
- Pages
- 9
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Biosystems Engineering
- Volume
- 48
- Number
- 4
- Start Page
- 503
- End Page
- 511
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/68970
- DOI
- 10.1007/s42853-023-00208-7
- ISSN
- 1738-1266
2234-1862
- Abstract
- Purpose: Over the past decade, cultured meat has attracted considerable attention as a sustainable alternative. Mimicking highly aligned muscle tissues and adipose tissues to replicate real meat poses a significant challenge to the development of cultured meat. Recently, techniques involving co-culture or post-assembly of different types of tissues have been introduced for cultured meat production. However, there is a need for a more straightforward approach for simultaneously replicating muscle and fat tissues. Methods: In this study, we developed nano-cultured meat that recapitulates the structural and physiological characteristics of real meat. GelMA was dissolved in an oil-in-water emulsion to create a fat bioink, and a fat scaffold was fabricated using a digital light processing-based 3D printer. Subsequently, the empty spaces within the fat scaffold were filled with myoblast-laden hydrogel, followed by integration with nanopatterns. Results: The resultant nano-cultured meat not only mimics highly aligned muscle tissue similar to real meat but also allows for the tunable reproduction of fat tissue. Conclusion: Overall, the proposed nano-cultured meat offers valuable insights for achieving a high level of maturity and developing customizable next-generation cultured meat. © 2023, The Author(s), under exclusive licence to The Korean Society for Agricultural Machinery.
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