Intravascular NK/T-cell lymphoma: a case report and literature reviewopen accessIntravascular NK/T-cell lymphoma: a case report and literature review
- Other Titles
- Intravascular NK/T-cell lymphoma: a case report and literature review
- Authors
- 나지민; 정욱재; 김민혜; 천윤홍; 이종실; 송대현; 양정욱
- Issue Date
- Nov-2023
- Publisher
- 대한병리학회
- Keywords
- Malignant lymphoma; Extranodal NK-T-cell lymphoma; Epstein-Barr virus
- Citation
- Journal of Pathology and Translational Medicine, v.57, no.6, pp 332 - 336
- Pages
- 5
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Journal of Pathology and Translational Medicine
- Volume
- 57
- Number
- 6
- Start Page
- 332
- End Page
- 336
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/68935
- DOI
- 10.4132/jptm.2023.10.30
- ISSN
- 2383-7837
2383-7845
- Abstract
- Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)–positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.
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