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Perilipin1 Expression as a Prognostic Factor in Patients with Squamous Cell Carcinoma of the Lungopen access

Authors
Kim, Min HyeLee, Jeong HeeLee, Jong SilKim, Dong ChulYang, Jung WookAn, Hyo JungNa, Ji MinJung, Wook JaeSong, Dae Hyun
Issue Date
Nov-2023
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
lipid metabolism; lung cancer; perilipin; prognosis; squamous cell carcinoma
Citation
Diagnostics, v.13, no.22
Indexed
SCIE
SCOPUS
Journal Title
Diagnostics
Volume
13
Number
22
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/68809
DOI
10.3390/diagnostics13223475
ISSN
2075-4418
Abstract
Perilipin (PLIN) is a major structural protein located on the surface of lipid droplets. PLIN plays an important role in human metabolism and is associated with metabolic diseases, such as obesity, diabetes, hypertension, and endocrine disorders. The dysregulation of lipid metabolism is one of the most prominent metabolic changes observed in cancers. Therefore, the PLIN protein family has recently attracted attention owing to its role in lipid metabolism and cancer. To date, no studies have addressed the association between the prognosis of lung cancer and PLIN1 expression. For the first time, we found that high PLIN1 expression was significantly correlated with worse disease-free survival (DFS) in lung squamous cell carcinoma (SCC). We examined PLIN1 expression by the immunohistochemical analysis of surgical lung SCC specimens obtained from 94 patients. We analyzed the correlation between PLIN1 expression, clinicopathological data, and patient survival, using a chi-squared test, Kaplan–Meier analysis with log-rank tests, and the multivariate Cox proportional hazards regression test. High PLIN1 expression was significantly correlated with lower DFS in the Kaplan–Meier analysis and the multivariate Cox proportional hazards regression model. High PLIN1 expression was significantly correlated with worse prognosis in lung SCC. © 2023 by the authors.
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