Bier’s Spots 환자 18예에 대한 분석: 후향적 단일기관 연구

Abstract

Background: Bier’s spots represent a distinct pattern of speckled vascular mottling composed of small, irregular anemic macules. This phenomenon is common and easily reproducible by placing an extremity in a dependent position when mild venous stasis is created. Objective: This study aimed to investigate the clinical manifestations of multiple anemic macules, Bier’s spots, and analyze its association with other underlying conditions in hospital outpatients. Methods: Between 2015∼2020, we reviewed clinical data of 18 patients diagnosed with Bier’s spots at our hospital. Analysis was performed to assess patient’s demographics, presentation, and treatment. Results: A total of 18 patients were included, and 10 (55.6%) were males. Lesions on both sides of the extremities were more common in 11 patients (61.1%), with four (22.2%) and two (11.1%) only on the upper and lower sides, respectively. Symptoms included itching in six patients (33.3%), numbness in two (11.1%), tenderness in one (5.6%), and asymptomatic in 11 (61.1%). The symptoms often accompanied hypertension, atopic dermatitis, and dyslipidemia. Histopathologic findings showed perivascular inflammation in six biopsy specimens, lymphocytic infiltration in four (66.7%), and papillary dermal vascular dilatation in three (50.0%). Calcium channel blockers and antihistamines were used for treatment in 13 patients (72.2%). Conclusion: The result shows clinical manifestations of Bier’s spots and a possibility of association with various underlying diseases. Optimum treatment for Bier’s spots has not been defined, and because most cases are asymptomatic, no treatment is required. Therefore, this study will be a valuable data of Bier’s spots for dermatologists.