Synergic Effect on Adipocytic Differentiation by a Combination of Thyroxine and Glucocorticoid in A549 CellsSynergic Effect on Adipocytic Differentiation by a Combination of Thyroxine and Glucocorticoid in A549 Cells
- Other Titles
- Synergic Effect on Adipocytic Differentiation by a Combination of Thyroxine and Glucocorticoid in A549 Cells
- Authors
- 김현지; 문선하; 이성호; 전병균
- Issue Date
- Sep-2023
- Publisher
- 한국생명과학회
- Keywords
- A549 adenocarcinoma; adipogenesis; anti-tumor; differentiation; human
- Citation
- 생명과학회지, v.33, no.9, pp.693 - 702
- Indexed
- KCI
- Journal Title
- 생명과학회지
- Volume
- 33
- Number
- 9
- Start Page
- 693
- End Page
- 702
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/68175
- ISSN
- 1225-9918
- Abstract
- The present study examined the rate of cell growth and differentiation potential into adipocytes in A549 lung adenocarcinoma cells exposed to each adipogenic medium containing glucose metabolism hormones, such as thyroxine (T4) thyroid hormone and glucocorticoid (GC) adrenal steroid hormone, as well as pioglitazone (PGZ), a PPARγ agonist. Following each adipogenic treatment for 2 weeks, the rate of cell growth was significantly (p<0.05) inhibited, and the level of telomerase activity was significantly (p<0.05) decreased in the PGZ-based adipogenic medium containing both T4 and GC hormone compared with those containing each T4 or GC hormone. Moreover, the adiposome-like vesicles were highly reacted with Oil-Red O staining solution, and the levels of transcripts expressed in the differentiating adipocytes for adipogenesis, including adinopectin, leptin, and resistin, were significantly (p<0.05) increased in the PGZ-based adipogenic medium containing both T4 and GC hormone compared with those of the adipogenic medium containing each T4 or GC hormone, implying that adipocytic differentiation has fully occurred in the A549 cancer cells. Based on present observations, the PGZ-based adipogenic medium containing both T4 and GC efficiently induces inhibition of cell growth and cellular differentiation into adipocytes in A549 cancer cells rather than in the adipogenic medium containing only T4 or GC hormone. Adipogenic treatment could provide potential probability in cancer chemotherapy.
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Collections - 사범대학 > 생물교육과 > Journal Articles
- 자연과학대학 > Division of Life Sciences > Journal Articles
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