Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs
- Hong, Sung Jin; Oh, Se Heang; Lee, Sung Lim; Kim, Na-Hyun; Choe, Yong Ho; Yim, Hyeong Jun; Lee, Jae-Hoon
- Issue Date
- SAGE PUBLICATIONS LTD
- Leaf-stacked scaffold; bone morphogenetic protein-2; bone regeneration; critical-sized bone defect; dog
- JOURNAL OF BIOMATERIALS APPLICATIONS, v.34, no.10, pp.1437 - 1448
- Journal Title
- JOURNAL OF BIOMATERIALS APPLICATIONS
- Start Page
- End Page
- The objective of this study was to investigate whether porous beads with a leaf-stacked scaffold loaded with bone morphogenetic protein-2, with sustained release for up to four weeks, were beneficial to a dog model of critical long bone defects and capable of promoting bone regeneration without side effects. Critical long bone defects were created in the femoral diaphyses of 21 dogs. Each critical defect was fixed with an intramedullary pin and an universal locking plate. Leaf-stacked scaffold beads were implanted into the defect, which was covered with a membrane. Nineteen samples were evaluated 4, 8, and 12 weeks after surgery using simple radiographs, serum chemistry measurements, histological staining, and gene expression analysis. Sustained bone morphogenetic protein-2 release from the leaf-stacked scaffold continued for four weeks and consistently affected the expression of early and late osteogenesis factors. The results suggest that sustained bone morphogenetic protein-2 release is effective for bone regeneration, with minimal side effects.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 수의과대학 > Department of Veterinary Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.