Periostin Plays a Key Role in Radioresistance of Head and Neck Cancer Cells Via Epithelial-to-Mesenchymal Transition
- Park, Jung Je; Hah, Young-Sool; Ryu, Somi; Cheon, So Young; Cho, Hee Young; Kim, Jin Pyeong; Won, Seong Jun; Lee, Jong Sil; Hwa, Jeong Seok; Seo, Ji Hyun; Chang, Hyo Won; Kim, Sang Yoon
- Issue Date
- INT INST ANTICANCER RESEARCH
- Periostin; radioresistance; head and neck cancer; epithelial-to-mesenchyma transition
- ANTICANCER RESEARCH, v.40, no.5, pp.2627 - 2635
- Journal Title
- ANTICANCER RESEARCH
- Start Page
- End Page
- Background/Aim: Head and neck squamous cell carcinoma (HNSCC) is an aggressive head and neck malignancy. The aim of this study was to elucidate the role of periostin (POSTN) in the epithelial-to-mesenchymal transition (EMT) process mediating the acquisition of radioresistance in HNSCC. Materials and Methods: The expression levels of EMT hallmark genes including POSTN and Erk/Akt signaling pathways were compared between radiosensitive and radioresistant HNSCC cells. Results: POSTN mRNA expression was higher in radioresistant HNSCC cells, and silencing POSTN significantly impaired their invasiveness under the effect of EMT process represented by up-regulation of mesenchymal markers and down-regulation of an epithelial marker. Expression levels of Erk and Akt were higher in radioresistant cells. Conclusion: POSTN in association with the Erk and Akt signaling pathways was up-regulated during the EMT process, leading to the conversion of radiosensitive to radioresistant HNSCC cells. POSTN may be a key marker for predicting the radioresistance and therapeutic target of HNSCC.
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- College of Medicine > Department of Medicine > Journal Articles
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