Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
- Kim, YI (Kim, Young-Il); Kim, SG (Kim, Seong-Gyu); Kim, SM (Kim, Se-Mi); Kim, EH (Kim, Eun-Ha); 박수진; Yu, KM (Yu, Kwang-Min); Chang, JH (Chang, Jae-Hyung); Kim, EJ (Kim, Eun Ji); Lee, S (Lee, Seunghun); Casel, MAB (Casel, Mark Anthon; Um, J (Um, Jihye); Song, MS (Song, Min-Suk); Jeong, HW (Jeong, Hye Won); Lai, VD (Lai, Van Dam); Kim, Y (Kim, Yeonjae); Chin, BS (Chin, Bum Sik); Park, JS (Park, Jun-Sun); Chung, KH (Chung, Ki-Hyun); Foo, SS (Foo, Suan-Sin); Poo, H (Poo, Haryoung); Mo, IP (Mo, In-Pil); Lee, OJ (Lee, Ok-Jun); Webby, RJ (Webby, Richard J.); Jung, JU (Jung, Jae U.); Choi, YK (Choi, Young Ki)...Mo
- Issue Date
- CELL PRESS
- CELL HOST MICROBE, v.27, no.5, pp.704 - 704
- Journal Title
- CELL HOST MICROBE
- Start Page
- End Page
- The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.
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- 자연과학대학 > Division of Life Sciences > Journal Articles
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