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Cited 17 time in webofscience Cited 15 time in scopus
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The impact of remission and coexisting migraine on anxiety and depression in cluster headacheopen access

Authors
Kim, Byung-SuChung, Pil-WookKim, Byung-KunLee, Mi JiPark, Jeong WookChu, Min KyungAhn, Jin-YoungBae, Dae WoongSong, Tae-JinSohn, Jong-HeeOh, KyungmiKim, DaeyoungKim, Jae-MoonKim, Soo-KyoungChoi, Yun-JuChung, Jae MyunMoon, Heui-SooChung, Chin-SangPark, Kwang-YeolCho, Soo-Jin
Issue Date
29-May-2020
Publisher
BMC
Keywords
Anxiety; Cluster headache; Depression; Headache; Migraine
Citation
JOURNAL OF HEADACHE AND PAIN, v.21, no.1
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF HEADACHE AND PAIN
Volume
21
Number
1
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/6594
DOI
10.1186/s10194-020-01120-7
ISSN
1129-2369
1129-2377
Abstract
Background Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. Methods We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of >= 10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods. Results Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35-15.99 and aOR = 4.95, 95% CI = 2.32-10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63-159.64 and aOR = 16.88, 95% CI = 4.16-68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 +/- 5.6 to 1.6 +/- 2.8; P < 0.001, and from 6.1 +/- 5.0 to 1.8 +/- 2.4; P < 0.001, respectively). Conclusions Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.
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