Cobalt-Catalyzed Direct C(sp(2))-H Alkylation with Unactivated Alkenes
- Authors
- Kim, Ye Lim; Park, Sun-a; Kim, Ju Hyun
- Issue Date
- 15-Jul-2020
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- C-H alkylation; Co(III)-catalyst; Phenylethyl group; Unactivated alkenes
- Citation
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2020, no.26, pp.4026 - 4030
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 2020
- Number
- 26
- Start Page
- 4026
- End Page
- 4030
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6396
- DOI
- 10.1002/ejoc.202000565
- ISSN
- 1434-193X
- Abstract
- A facile and efficient method for Cp*Co-III-catalyzed C(sp(2))-H bond alkylation was developed using 2-aryl pyridines and unactivated alkenes. The reaction proceeded atom-economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono-diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram-scale reaction and further C-H bond functionalizations of the mono-alkylated product were performed.
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