Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Developmentopen access
- Authors
- Idrees, Muhammad; Oh, Seon-Hwa; Muhammad, Tahir; El-Sheikh, Marwa; Song, Seok-Hwan; Lee, Kyeong-Lim; Kong, Il-Keun
- Issue Date
- Aug-2020
- Publisher
- MDPI
- Keywords
- SHP2; growth factors; cytokines; gametogenesis; embryo development
- Citation
- CELLS, v.9, no.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLS
- Volume
- 9
- Number
- 8
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6387
- DOI
- 10.3390/cells9081798
- Abstract
- Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors and cytokines to integrate with and trigger protein signaling in the germ and embryo intracellular milieu. Src-homology-2-containing phosphotyrosine phosphatase (SHP2) is a ubiquitously expressed, multifunctional protein that plays a central role in the signaling pathways involved in growth factor receptors, cytokine receptors, integrins, and G protein-coupled receptors. Over recent decades, researchers have recapitulated the protein signaling networks that influence gamete progenitor specification as well as gamete differentiation and maturation. SHP2 plays an indispensable role in cellular growth, survival, proliferation, differentiation, and migration, as well as the basic events in gametogenesis and early embryo development. SHP2, a classic cytosolic protein and a key regulator of signal transduction, displays unconventional nuclear expression in the genital organs. Several observations provided shreds of evidence that this behavior is essential for fertility. The growth factor and cytokine-dependent roles of SHP2 and its nuclear/cytoplasmic presence during gamete maturation, early embryonic development and embryo implantation are fascinating and complex subjects. This review is intended to summarize the previous and recent knowledge about the SHP2 functions in gametogenesis and early embryo development.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/6387)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.