Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort studyopen access
- Kim, Jae Ri; Jang, Kee-Taek; Jang, Jin-Young; Lee, Kyungbun; Kim, Jung Hoon; Kim, Haeryoung; Kim, Sun-Whe; Kwon, Wooil; Choi, Dong Wook; Heo, JinSeok; Han, In Woong; Hwang, Shin; Kim, Wan-Joon; Hong, Seung-Mo; Kim, Dong-Sik; Yu, Young-Dong; Kim, Joo Young; Nah, Yang Won; Park, Hyung Woo; Choi, Hye-Jeong; Han, Ho-Seong; Yoon, Yoo-Seok; Park, Sang Jae; Hong, Eun Kyung; Seo, Hyung Il; Park, Do Youn; Kang, Koo Jeong; Kang, Yu Na; Yu, Hee Chul; Moon, Woo Sung; Lim, Chang-Sup; Bae, Jeong Mo; Jo, Sungho; Lee, Wonae; Roh, Young Hun; Jeong, Jin Sook; Jeong, Chi-Young; Lee, Jong Sil; Song, In-Sang; Kim, Kyung-Hee; Kim, Ho Gak; Cho, Chang Ho; Joo, Sun-Hyung; Won, Kyu Yeoun; Kim, Hong Jin; Choi, Joon Hyuk; Chu, Chong-Woo; Lee, Jung Hee; Park, Il Young; Lee, Heejeong; Lee, Seung Eun; Kim, Hee Sung; Lee, Hyeon Kook; Cho, Min-Sun; Kim, Hongbeom; Han, Kang Min
- Issue Date
- ELSEVIER SCI LTD
- HPB, v.22, no.8, pp.1139 - 1148
- Journal Title
- Start Page
- End Page
- Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the "Jang & Kim's modified anatomical classification," 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010-4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.
- Files in This Item
- There are no files associated with this item.
- Appears in
- College of Medicine > Department of Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.