Detailed Information

Cited 4 time in webofscience Cited 6 time in scopus
Metadata Downloads

Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-alpha via Inhibiting JNK Signalingopen access

Authors
Park, Jin-HoKang, Young-HoonHwang, Sun-ChulOh, Se HeangByun, June-Ho
Issue Date
Aug-2020
Publisher
MDPI
Keywords
parthenolide; TNF-alpha; periosteum-derived cells; osteoblastic differentiation; JNK signaling
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.15
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
21
Number
15
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6332
DOI
10.3390/ijms21155433
ISSN
1661-6596
Abstract
Nuclear factor kappa B (NF-kappa B) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-kappa B. Parthenolide (PTL) is an abundant sesquiterpene lactone, found in Mexican Indian Asteraceae family plants, with reported anti-inflammatory activity, through the inhibition of a common step in the NF-kappa B activation pathway. This study examined the effects of PTL on the enhanced, in vitro, osteogenic phenotypes of human periosteum-derived cells (hPDCs), mediated by the inflammatory cytokine tumor necrosis factor (TNF)-alpha. PTL had no significant effects on hPDC viability or osteoblastic activities, whereas TNF-alpha had positive effects on the in vitro osteoblastic differentiation of hPDCs. c-Jun N-terminal kinase (JNK) signaling played an important role in the enhanced osteoblastic differentiation of TNF-alpha-treated hPDCs. Treatment with 1 mu M PTL did not affect TNF-alpha-treated hPDCs; however, 5 and 10 mu M PTL treatment decreased the histochemical detection and activity of alkaline phosphatase (ALP), alizarin red-positive mineralization, and the expression of ALP and osteocalcin mRNA. JNK phosphorylation decreased significantly in TNF-alpha-treated hPDCs pretreated with PTL. These results suggested that PTL exerts negative effects on the increased osteoblastic differentiation of TNF-alpha-treated hPDCs by inhibiting JNK signaling.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Hwang, Sun Chul photo

Hwang, Sun Chul
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE