Enantioselective organocatalytic Michael reactions using chiral (R,R)-1,2-diphenylethylenediamine-derived thioureasopen access
- Shim, Jae Ho; Lee, Min Ji; Lee, Min Ho; Kim, Byeong-Seon; Ha, Deok-Chan
- Issue Date
- ROYAL SOC CHEMISTRY
- RSC ADVANCES, v.10, no.53, pp.31808 - 31814
- Journal Title
- RSC ADVANCES
- Start Page
- End Page
- Although the Michael addition is a very well-known and widely applied reaction, cost-effective, metal-free, and readily prepared organic catalysts remain rare. A chiral, bifunctional, (R,R)-1,2-diphenylethylenediamine-derived thiourea organic catalyst was developed and applied to asymmetric Michael additions of nitroalkenes under neutral conditions. Generally, fluorine-substituted thiourea catalysts exhibited high chemical yields and enantioselectivities under neutral conditions. The mild reactions were tolerant of many functional groups and afforded good-to-excellent yields, as well as high diastereo- and enantioselectivities for the Michael adducts. The utility of the transformation was demonstrated by the synthesis of a bioactive compound, (R)-Phenibut.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 사범대학 > 화학교육과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.