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Cited 5 time in webofscience Cited 5 time in scopus
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Monitoring Insecticide Resistance and Target Site Mutations of L1014 Kdr And G119 Ace Alleles in Five Mosquito Populations in Koreaopen access

Authors
Park, Seo HyeJun, HojongAhn, Seong KyuLee, JinyoungYu, Sung-LimLee, Sung KeunKang, Jung-MiKim, HyunwooLee, Hee-IlHong, Sung-JongNa, Byoung-KukBahk, Young YilKim, Tong-Soo
Issue Date
Oct-2020
Publisher
대한기생충학ㆍ열대의학회
Keywords
kdr; ace; insecticide resistance; mutation
Citation
The Korean Journal of Parasitology, v.58, no.5, pp 543 - 550
Pages
8
Indexed
SCIE
SCOPUS
KCI
Journal Title
The Korean Journal of Parasitology
Volume
58
Number
5
Start Page
543
End Page
550
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/6142
DOI
10.3347/kjp.2020.58.5.543
ISSN
0023-4001
1738-0006
Abstract
Mosquitoes are globally distributed and important vectors for the transmission of many human diseases. Mosquito control is a difficult task and the cost of preventing mosquito-borne diseases is much lower than that for curing the associated diseases. Thus, chemical control remains the most effective tool for mosquito. Due to the long-term intensive use of insecticides to control mosquito vectors, resistance to most chemical insecticides has been reported. This study aimed to investigate the relationship between insecticide resistance and target site mutation of L1014 kdr and G119 ace alleles in 5 species/species group of mosquitoes (Aedes vexans, Ae. albopictus, Anopheles spp., Culex pipiens complex, and Cx. tritaeniorhynchus) obtained from 6 collection sites. For Anopheles spp., the proportion of mosquitoes with mutated alleles in L1014 was 88.4%, homozygous resistant genotypes were observed in 46.7%, and heterozygous resistant genotypes were observed in 41.8%. For the Cx. pipiens complex and Cx. tritaeniorhynchus species, homozygous resistant genotypes were found in 25.9% and 9.8%, respectively. However, target site mutation of L1014 in the Ae. vexans nipponii and Ae. albopictus species was not observed. Anopheles spp., Cx. pipiens complex, and Cx. tritaeniorhynchus mosquitoes were resistant to deltamethrin and chlorpyriphos, whereas Ae. vexans nipponii and Ae. albopictus were clearly susceptible. We also found a correlation between the resistance phenotype and the presence of the L1014 kdr and G119 ace mutations only in the Anopheles spp. population. In this study, we suggest that insecticide resistance poses a growing threat and resistance management must be integrated into all mosquito control programs.
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의과대학 (의학과)
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