Detailed Information

Cited 41 time in webofscience Cited 41 time in scopus
Metadata Downloads

Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: short-term outcomes of a multicentre randomized controlled trial (SENORITA)

Authors
An, J. Y.Min, J-SHur, H.Lee, Y. J.Cho, G. S.Park, Y-KJung, M. R.Park, J-HHyung, W. J.Jeong, S-HKim, Y-WYoon, H. M.Eom, B. W.Kook, M-CHan, M. R.Name, B-HRyu, K. W.
Issue Date
Oct-2020
Publisher
John Wiley & Sons Inc.
Citation
British Journal of Surgery, v.107, no.11, pp 1429 - 1438
Pages
10
Indexed
SCIE
SCOPUS
Journal Title
British Journal of Surgery
Volume
107
Number
11
Start Page
1429
End Page
1438
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/6137
DOI
10.1002/bjs.11655
ISSN
0007-1323
1365-2168
Abstract
Background Sentinel node navigation surgery reduces the extent of gastric and lymph node dissection, and may improve quality of life. The benefit and harm of laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer is unknown. The SENORITA (SEntinel Node ORIented Tailored Approach) trial investigated the pathological and surgical outcomes of LSNNS compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection. Methods The SENORITA trial was an investigator-initiated, open-label, parallel-assigned, non-inferiority, multicentre RCT conducted in Korea. The primary endpoint was 3-year disease-free survival. The secondary endpoints, morbidity and mortality within 30 days of surgery, are reported in the present study. Results A total of 580 patients were randomized to LSG (292) or LSNNS (288). Surgery was undertaken in 527 patients (LSG 269, LSNNS 258). LSNNS could be performed according to the protocol in 245 of 258 patients, and a sentinel node basin was detected in 237 (96 center dot 7 per cent) Stomach-preserving surgery was carried out in 210 of 258 patients (81 center dot 4 per cent). Postoperative complications occurred in 51 patients in the LSG group (19 center dot 0 per cent) and 40 (15 center dot 5 per cent) in the LSNNS group (P = 0 center dot 294). Complications with a Clavien-Dindo grade of III or higher occurred in 16 (5 center dot 9 per cent) and 13 (5 center dot 0 per cent) patients in the LSG and LSNNS groups respectively (P = 0 center dot 647). Conclusion The rate and severity of complications following LSNNS for early gastric cancer are comparable to those after LSG with lymph node dissection. Registration number: NCT01804998 ( ).
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jeong, Sang Ho photo

Jeong, Sang Ho
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE