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Cited 58 time in webofscience Cited 61 time in scopus
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The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralismopen access

Authors
Kim, KwondoKwon, TaehyungDessie, TadelleYoo, DongAhnMwai, Okeyo AllyJang, JisungSung, SamsunLee, SaetByeolSalim, BashirJung, JaehoonJeong, HeesuTarekegn, Getinet MekuriawTijjani, AbdulfataiLim, DajeongCho, SeoaeOh, Sung JongLee, Hak-KyoKim, JaeminJeong, ChoongwonKemp, StephenHanotte, OlivierKim, Heebal
Issue Date
Oct-2020
Publisher
Nature Publishing Group
Citation
Nature Genetics, v.52, no.10, pp 1099 - +
Indexed
SCIE
SCOPUS
Journal Title
Nature Genetics
Volume
52
Number
10
Start Page
1099
End Page
+
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/6136
DOI
10.1038/s41588-020-0694-2
ISSN
1061-4036
1546-1718
Abstract
Whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds identifies 16 loci linked to environmental adaptations among crossbred animals, including a highly divergent locus in African taurine cattle putatively linked to trypanotolerance. Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine x indicine cattle admixture event dated to circa 750-1,050 yr ago, which has shaped the genome of today's cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.
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Kim, Jae Min
대학원 (응용생명과학부)
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