Antihistamine Activity of Steam-exploded Oak Extract Containing Phenolic Compoundsopen access
- Jung, Ji Young; Ha, Si Young; Kim, Tae-Heung; Yang, Jae-Kyung
- Issue Date
- NORTH CAROLINA STATE UNIV DEPT WOOD & PAPER SCI
- Oak; steam explosion; Phenolic compound; Antioxidant activity; Antihistamine activity
- BIORESOURCES, v.15, no.4, pp.8770 - 8783
- Journal Title
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- The aim of this study was to investigate the antihistamine activity of steam-exploded oak (Quercus variabilis) extract containing phenolic compounds. The antioxidant activity increased with residence time of the steam explosion process. The 50% EtOH extract had total phenolic compound content of 82.2 % and 46.2 mg GAE/g extract and vanillic acid, ferulic acid, and vanillin were identified. Treatment with 50% EtOH extract decreased the diameters of histamine-induced wheal and erythema responses in human volunteers. In patients with atopic dermatitis, topical administration of 50% EtOH extract led to significant diseases and improvement in terms of sleep disturbance, pruritus, xerosis, desire to scratch, and erythema. This study suggested that steam-exploded oak is rich in phenolic compounds with high antioxidant and antihistamine activities, and the extract may be a promising source of new antihistamine agents and pharmaceuticals.
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- 농업생명과학대학 > Department of Environmental Materials Science > Journal Articles
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