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Cited 5 time in webofscience Cited 7 time in scopus
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Inositol-requiring enzyme 1 (IRE1) plays for AvrRpt2-triggered immunity and RIN4 cleavage in Arabidopsis under endoplasmic reticulum (ER) stress

Authors
Chakraborty, RupakUddin, ShahabMacoy, Donah MaryPark, Si OnDuong Thu Van AnhRyu, Gyeong RyulKim, Young HunLee, Jong-YeolCha, Joon-YungKim, Woe-YeonLee, Sang YeolKim, Min Gab
Issue Date
Nov-2020
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Keywords
ER stress; Tunicamycin; UPR; IRE1; Bacterial growth; RIN4
Citation
PLANT PHYSIOLOGY AND BIOCHEMISTRY, v.156, pp.105 - 114
Indexed
SCIE
SCOPUS
Journal Title
PLANT PHYSIOLOGY AND BIOCHEMISTRY
Volume
156
Start Page
105
End Page
114
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/5974
DOI
10.1016/j.plaphy.2020.09.002
ISSN
0981-9428
Abstract
Many stresses induce the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum, a phenomenon known as ER stress. In response to ER stress, cells initiate a protective response, known as unfolded protein response (UPR), to maintain cellular homeostasis. The UPR sensor, inositol-requiring enzyme 1 (IRE1), catalyzes the cytoplasmic splicing of bZIP transcription factor-encoding mRNAs to activate the UPR signaling pathway. Recently, we reported that pretreatment of Arabidopsis thaliana plants with tunicamycin, an ER stress inducer, increased their susceptibility to bacterial pathogens; on the other hand, IRE1 deficient mutants were susceptible to Pseudomonas syringae pv. maculicola (Psm) and failed to induce salicylic acid (SA)-mediated systemic acquired resistance. However, the functional relationship of IRE1 with the pathogen and TM treatment remains unknown. In the present study, we showed that bacterial pathogen-associated molecular patterns (PAMPs) induced IRE1 expression; however, PAMP-triggered immunity (PTI) response such as callose deposition, PR1 protein accumulation, or Pst DC3000 hrcC growth was not altered in ire1 mutants. We observed that IRE1 enhanced plant immunity against the bacterial pathogen P. syringae pv. tomato DC3000 (Pst DC3000) under ER stress. Moreover, TM-pretreated ire1 mutants were more susceptible to the avirulent strain Pst DC3000 (AvrRpt2) and showed greater cell death than wild-type plants during effector-triggered immunity (ETI). Additionally, Pst DC3000 (AvrRpt2)-mediated RIN4 degradation was reduced in ire1 mutants under TM-induced ER stress. Collectively, our results reveal that IRE1 plays a pivotal role in the immune signaling pathway to activate plant immunity against virulent and avirulent bacterial strains under ER stress.
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