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Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hahn, Dongyup | - |
| dc.contributor.author | Shin, Seung Ho | - |
| dc.contributor.author | Bae, Jong-Sup | - |
| dc.date.accessioned | 2022-12-26T12:15:39Z | - |
| dc.date.available | 2022-12-26T12:15:39Z | - |
| dc.date.issued | 2020-12 | - |
| dc.identifier.issn | 2076-3921 | - |
| dc.identifier.issn | 2076-3921 | - |
| dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/5859 | - |
| dc.description.abstract | Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that catalyzes heme group degradation. Decreased level of HO-1 is correlated with disease progression, and HO-1 induction suppresses development of metabolic and neurological disorders. Natural compounds with antioxidant activities have emerged as a rich source of HO-1 inducers with marginal toxicity. Here we discuss the therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson's disease and hepatic fibrosis, and present important signaling pathway components that lead to HO-1 expression. We provide an updated, comprehensive list of natural HO-1 inducers in foodstuff and medicinal herbs categorized by their chemical structures. Based on the continued research in HO-1 signaling pathways and rapid development of their natural inducers, HO-1 may serve as a preventive and therapeutic target for metabolic and neurological disorders. | - |
| dc.format.extent | 40 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | MDPI | - |
| dc.title | Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression | - |
| dc.type | Article | - |
| dc.publisher.location | 스위스 | - |
| dc.identifier.doi | 10.3390/antiox9121191 | - |
| dc.identifier.scopusid | 2-s2.0-85096821489 | - |
| dc.identifier.wosid | 000602198100001 | - |
| dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.9, no.12, pp 1 - 40 | - |
| dc.citation.title | ANTIOXIDANTS | - |
| dc.citation.volume | 9 | - |
| dc.citation.number | 12 | - |
| dc.citation.startPage | 1 | - |
| dc.citation.endPage | 40 | - |
| dc.type.docType | Review | - |
| dc.description.isOpenAccess | Y | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Food Science & Technology | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
| dc.subject.keywordPlus | NF-KAPPA-B | - |
| dc.subject.keywordPlus | ACID PHENETHYL ESTER | - |
| dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
| dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
| dc.subject.keywordPlus | LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION | - |
| dc.subject.keywordPlus | VASCULAR ENDOTHELIAL-CELLS | - |
| dc.subject.keywordPlus | PDGF-INDUCED PROLIFERATION | - |
| dc.subject.keywordPlus | LPS-INDUCED INFLAMMATION | - |
| dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
| dc.subject.keywordPlus | P38 MAPK/NRF2 PATHWAY | - |
| dc.subject.keywordAuthor | heme oxygenase-1 | - |
| dc.subject.keywordAuthor | antioxidant | - |
| dc.subject.keywordAuthor | anti-inflammatory compound | - |
| dc.subject.keywordAuthor | foodstuff | - |
| dc.subject.keywordAuthor | medicinal herbs | - |
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