Paeoniflorin ameliorates A beta-stimulated neuroinflammation via regulation of NF-kappa B signaling pathway and A beta degradation in C6 glial cells
DC Field | Value | Language |
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dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Lee, Ah Young | - |
dc.date.accessioned | 2022-12-26T12:04:41Z | - |
dc.date.available | 2022-12-26T12:04:41Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/5832 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Alzheimer's disease is common age-related neurodegenerative condition characterized by amyloid beta (A beta) accumulation that leads cognitive impairment. In the present study, we investigated the protective effect of paeoniflorin (PF) against A beta-induced neuroinflammation and the underlying mechanism in C6 glial cells. MATERIALS/METHODS: C6 glial cells were treated with PF and A beta(25-35), and cell viability, nitric oxide (NO) production, and pro-inflammatory cytokine release were measured. Furthermore, the mechanism underlying the effect of PF on inflammatory responses and A beta degradation was determined by Western blot. RESULTS: A beta(2)(5-)(35) significantly reduced cell viability, but this reduction was prevented by the pretreatment with PF. In addition, PF significantly inhibited A beta(2)(5-)(35)-induced NO production in C6 glial cells. The secretion of interleukin (IL)-6, IL-1 beta, and tumor necrosis factor-alpha was also significantly reduced by PF. Further mechanistic studies indicated that PF suppressed the production of these pro-inflammatory cytokines by regulating the nuclear factor-kappa B (NF-kappa B) pathway. The protein levels of inducible NO synthase and cyclooxygenase-2 were downregulated and phosphorylation of NF-kappa B was blocked by PF. However, PF elevated the protein expression of inhibitor kappa B-alpha and those of A beta degrading enzymes, insulin degrading enzyme and neprilysin. CONCLUSIONS: These findings indicate that PF exerts protective effects against A beta-mediated neuroinflammation by inhibiting NF-kappa B signaling, and these effects were associated with the enhanced activity of A beta degradation enzymes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.subject | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | INFLAMMATORY RESPONSES | - |
dc.subject | MONOTERPENE GLYCOSIDE | - |
dc.subject | PAEONIAE-RADIX | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | IN-VITRO | - |
dc.subject | ASTROCYTES | - |
dc.subject | BRAIN | - |
dc.subject | NEUROTOXICITY | - |
dc.title | Paeoniflorin ameliorates A beta-stimulated neuroinflammation via regulation of NF-kappa B signaling pathway and A beta degradation in C6 glial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Young | - |
dc.contributor.affiliatedAuthor | Lee, Ah Young | - |
dc.identifier.doi | 10.4162/nrp.2020.14.6.593 | - |
dc.identifier.scopusid | 2-s2.0-85097313844 | - |
dc.identifier.wosid | 000592261900004 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.14, no.6, pp.593 - 605 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 593 | - |
dc.citation.endPage | 605 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002647243 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | MONOTERPENE GLYCOSIDE | - |
dc.subject.keywordPlus | PAEONIAE-RADIX | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ASTROCYTES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordAuthor | Paeonia | - |
dc.subject.keywordAuthor | neurodegenerative diseases | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | NF-kappaB | - |
dc.subject.keywordAuthor | glial cells | - |
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