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Paeoniflorin ameliorates A beta-stimulated neuroinflammation via regulation of NF-kappa B signaling pathway and A beta degradation in C6 glial cells

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dc.contributor.authorCho, Eun Ju-
dc.contributor.authorKim, Hyun Young-
dc.contributor.authorLee, Ah Young-
dc.date.accessioned2022-12-26T12:04:41Z-
dc.date.available2022-12-26T12:04:41Z-
dc.date.created2022-12-13-
dc.date.issued2020-12-
dc.identifier.issn1976-1457-
dc.identifier.urihttps://scholarworks.bwise.kr/gnu/handle/sw.gnu/5832-
dc.description.abstractBACKGROUND/OBJECTIVES: Alzheimer's disease is common age-related neurodegenerative condition characterized by amyloid beta (A beta) accumulation that leads cognitive impairment. In the present study, we investigated the protective effect of paeoniflorin (PF) against A beta-induced neuroinflammation and the underlying mechanism in C6 glial cells. MATERIALS/METHODS: C6 glial cells were treated with PF and A beta(25-35), and cell viability, nitric oxide (NO) production, and pro-inflammatory cytokine release were measured. Furthermore, the mechanism underlying the effect of PF on inflammatory responses and A beta degradation was determined by Western blot. RESULTS: A beta(2)(5-)(35) significantly reduced cell viability, but this reduction was prevented by the pretreatment with PF. In addition, PF significantly inhibited A beta(2)(5-)(35)-induced NO production in C6 glial cells. The secretion of interleukin (IL)-6, IL-1 beta, and tumor necrosis factor-alpha was also significantly reduced by PF. Further mechanistic studies indicated that PF suppressed the production of these pro-inflammatory cytokines by regulating the nuclear factor-kappa B (NF-kappa B) pathway. The protein levels of inducible NO synthase and cyclooxygenase-2 were downregulated and phosphorylation of NF-kappa B was blocked by PF. However, PF elevated the protein expression of inhibitor kappa B-alpha and those of A beta degrading enzymes, insulin degrading enzyme and neprilysin. CONCLUSIONS: These findings indicate that PF exerts protective effects against A beta-mediated neuroinflammation by inhibiting NF-kappa B signaling, and these effects were associated with the enhanced activity of A beta degradation enzymes.-
dc.language영어-
dc.language.isoen-
dc.publisherKOREAN NUTRITION SOC-
dc.subjectPERFORMANCE LIQUID-CHROMATOGRAPHY-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectINFLAMMATORY RESPONSES-
dc.subjectMONOTERPENE GLYCOSIDE-
dc.subjectPAEONIAE-RADIX-
dc.subjectNITRIC-OXIDE-
dc.subjectIN-VITRO-
dc.subjectASTROCYTES-
dc.subjectBRAIN-
dc.subjectNEUROTOXICITY-
dc.titlePaeoniflorin ameliorates A beta-stimulated neuroinflammation via regulation of NF-kappa B signaling pathway and A beta degradation in C6 glial cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Hyun Young-
dc.contributor.affiliatedAuthorLee, Ah Young-
dc.identifier.doi10.4162/nrp.2020.14.6.593-
dc.identifier.scopusid2-s2.0-85097313844-
dc.identifier.wosid000592261900004-
dc.identifier.bibliographicCitationNUTRITION RESEARCH AND PRACTICE, v.14, no.6, pp.593 - 605-
dc.relation.isPartOfNUTRITION RESEARCH AND PRACTICE-
dc.citation.titleNUTRITION RESEARCH AND PRACTICE-
dc.citation.volume14-
dc.citation.number6-
dc.citation.startPage593-
dc.citation.endPage605-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART002647243-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaNutrition & Dietetics-
dc.relation.journalWebOfScienceCategoryNutrition & Dietetics-
dc.subject.keywordPlusPERFORMANCE LIQUID-CHROMATOGRAPHY-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusINFLAMMATORY RESPONSES-
dc.subject.keywordPlusMONOTERPENE GLYCOSIDE-
dc.subject.keywordPlusPAEONIAE-RADIX-
dc.subject.keywordPlusNITRIC-OXIDE-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusASTROCYTES-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusNEUROTOXICITY-
dc.subject.keywordAuthorPaeonia-
dc.subject.keywordAuthorneurodegenerative diseases-
dc.subject.keywordAuthoramyloid-
dc.subject.keywordAuthorNF-kappaB-
dc.subject.keywordAuthorglial cells-
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